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Most IAPs have a RING domain at their C-terminus that is required for ubiquitination of their substrates as well as auto-ubiquitination of some members including c-IAP1, c-IAP2 and X-linked inhibitor of apoptosis (XIAP) 61,62
The steps below are for informational purposes only
Nrf2 is released from the Nrf2Keap1 system and then translocates to the cell nucleus, where it combines with small musculoaponeurotic fibrosarcoma (sMAF) proteins to form heterodimers
In fulfilling this protective role, reduced glutathione is converted into oxidized glutathione, at which point it becomes inactive
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