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They recognize that clinical trials showed modest effects (average 2.6 kg over 12 weeks in responders), appreciate that individual response varies significantly, commit to proper nutrition and exercise foundations, and accept that the peptide is used for research purposes under medical supervision

We hypothesized that MOTS-c can mimic the effects of exercise by improving cardiac dysfunction in a rat model of T2DM.The underlying mechanism may be that MOTS-c improves the oxidative stress pathway involving Kelch-like ECH-associated protein 1 (Keap1)Nrf2