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In addition to Trx, S -nitrosoglutathione reductase (GSNOR) plays a predominant role in protein denitrosylation (Benhar et al., 2009)
Proctor CJC Pediatric and Congenital Heart Disease.2026
Without a clear clinical pathway, GLP-1 usage becomes indefinite and so does the cost
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It is a common form of heart failure in patients with obesity, hypertension, and metabolic syndrome, and it has become a recognized clinical target for incretin-based therapy following the STEP-HFpEF trial (semaglutide in HFpEF with obesity) and the SUMMIT trial (tirzepatide in obesity-related HFpEF)
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