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Those with certain conditions: Milk thistle can have estrogenic effects, which may worsen hormone-sensitive conditions, including some types of breast cancer
These include cold and flu symptoms, signs of hypoglycemia, abdominal pain, nausea, vomiting, constipation, diarrhea, fatigue and allergic and adverse reactions
Andersson LE, Valtat B, Bagge A et al (2015) Characterization of stimulus-secretion coupling in the human pancreatic EndoC-betaH1 beta cell line
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