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These strategies offer several potential advantages over GLP-1 analogs, including a more natural stimulation of GLP-1 pathways, reduced risk of side effects, and the ability to address metabolic dysregulation at its source However, clinical applicability for pharmacological targets to increase sufficient GLP-1 production and promote L-cell differentiation has not been identified
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Biochim Biophys Acta 1780:127390
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