Should it still be the first-line agent, or have newer drug classes like GLP1 receptor agonists and SGLT2 inhibitors earned Read More GLP1s and Liver Disease: Rethinking MASLD Care Beyond Obesity and A1C Jan 26, 2026 Articles, Diabetes, Featured, Obesity, Therapies, Type 2 Diabetes, Type 2 Diabetes 2,788 views Nonalcoholic steatohepatitis (NASH) and metabolic dysfunctionassociated steatotic liver disease (MASLD) are rapidly becoming leading causes of chronic liver disease worldwide
Live imaging reveals a new role for the sigma-1 (1) receptor in allowing microglia to leave brain injuries
Carcinogenesis 31:804811

[31] A large study found that GLP-1 RA use was associated with lower risk of developing immune-mediated inflammatory diseases in patients with type 2 diabetes or obesity, suggesting a potential protective effect in some cohorts.[42] What the science is showing is potential for improvements: GLP-1RAs reduce blunt activation in fibroblast-like synoviocytes and improve joint inflammation and metabolic parameters in rheumatoid arthritis models and small human cohorts.[26][29][25] [31] Early clinical studies and case series in RA patients (especially those with coexisting type 2 diabetes or obesity) reported reduced disease activity scores (DAS28), lower C-reactive protein and erythrocyte sedimentation rate levels, fewer swollen joints, and diminished morning stiffness during GLP-1RA treatment, along with the expected weight reduction and improved insulin sensitivity.[31] Psoriasis showed improved PASI scores and quality-of-life metrics in patients with T2DM and psoriasis, alongside reductions in lesional skin and peripheral TNF-producing monocytes.[26] Case series show meaningful skin improvement.[26] In psoriasis and psoriatic arthritis , GLP-1RA therapy has been associated with improvements in inflammatory markers and disease severity indices
