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Semaglutide works by activating GLP-1 receptors, which help reduce appetite and slow stomach emptying
Treatment decisions may involve dose timing, supportive care, or considering another option
Landsberg was the first researcher speculating that increased SNS activity in response to weight gain is an adaptive mechanism to increase resting energy expenditure and promote restoration of the antecedent weight (Landsberg, 1986, 2001), while other authors suggested that prolonged sympathetic overactivity might induce weight gain, due to reduced capacity to dissipate excessive calories, mediated by downregulation of adrenoceptors (van Baak, 2001
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