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Multiple studies have illustrated that there is an increase in pneumonia incidence immediately before PPI use as well as after (Wang et al
In trials (DURATION program), once-weekly exenatide 2 mg showed slightly more A1c reduction (~1.5% drop from baseline 8.3%) than Byetta BID (~1.0% drop) with fewer GI side effects after initial weeks ( [6] )
Over the subsequent 48 weeks, participants who continued semaglutide experienced an additional mean weight loss of 7.9%, whereas those switched to placebo regained 6.9% of body weight, resulting in a significant 14.8 percentage-point treatment difference
National Institute on Aging
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