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The net result of treatment is an increased cellular uptake of LDL, since the intracellular synthesis of cholesterol is inhibited and cells are therefore dependent on extracellular sources of cholesterol
Metabolic Health & Insulin Sensitivity Modulation of NNMT activity has been associated with improved glucose handling and insulin sensitivity, suggesting potential benefits in metabolic syndrome and related conditions
Always follow the manufacturer's recommended titration schedule in the SmPC, and consider extending the time at lower doses if patients experience significant gastrointestinal symptoms
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