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As further GIP-GLP-1 receptor co-agonists were developed those findings were confirmed [51]
The SURPASS trials, which tested tirzepatide across populations with varying baseline metformin use, showed that adding tirzepatide to existing metformin therapy produced A1C reductions of 1.5 to 2.5 percentage points and average weight loss of 12 to 22 pounds over 40 weeks
It has been studied extensively and has a strong safety record
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