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Studies have shown that when NNMTi is combined with a lowcalorie diet, the rate of body weight loss in obese mice is significantly faster than in either singleintervention group, with more pronounced reduction of adipose tissue and greater improvement in insulin sensitivity and hepatic metabolism

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Treatment with 5 M C1-27 for 24 h resulted in an increase in the S-phase population, with a concomitant decrease in the G0/G1 population (Fig