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Key Findings: Asian participants: 21.3% mean weight loss with CagriSema (similar to overall population) Safety profile consistent across ethnicities GI tolerability similar but potentially lower discontinuation rates in Asian populations Clinical Significance: Supports global applicability of cagrilintide-based therapies across diverse populations
Regulatory Documentation: Transferred processes often require regulatory filings (e.g
Half of the volunteers were taking one of three GLP-1 medicationssemaglutide, tirzepatide, or liraglutidewhile the other half werent on any of these drugs
Additionally, agonists of GLP-1R have been associated with reduced fasting very low-density lipoprotein (VLDL), which was shown to be weight-independent [20, 21]
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