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Long-Acting GLP-1 RAs Exenatide (Bydureon) In 1987, scientists discovered that GLP-1 promotes insulin secretion, and five years later, an entero-insulin analogue, Exendin-4, which is 53% homologous to GLP-1, was isolated from the saliva of the Mexican giant lizard, later known as exenatide, which has GLP-1 receptor agonist activity and a half-life of 2.4 hours

Tirzepatide, approved as Mounjaro for diabetes, has been studied in comparison to semaglutide for weight loss, demonstrating an impressive average weight loss of 22.5% of body weight over 72 weeks