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Gastrointestinal issues: While some gastrointestinal side effects are common initially, people with severe disorders may need to be monitored closely or may not be suitable candidates

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VSMCs are stimulated by various pathological factors (such as mechanical stress changes and inflammatory factors), and the glucose metabolism pattern is converted to the promotion of glycolytic flux, the reduction of PPP and mitochondrial metabolism, accompanied by phenotypic conversion to synthesis, osteogenic, foam cell, and inflammatory types