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In abdominal aorta anastomosis models, the peptide prevents and reverses thrombus formation, suggesting antithrombotic effects mediated through endothelial protection and normalized coagulation cascade activity
GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically
For more information on micronutrients and phytochemicals related to cognitive decline or neurodegenerative diseases, see the article on Micronutrients for Older Adults
Suryawanshi K, Sutar P, Khot A, Mushrif A
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