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The researchers also observed enhanced autophagy in cardiac muscle cells
PMID 26915364
Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging
Given that active demethylation occurs on numerous neighboring CGs, as shown during electro-convulsive treatment-induced neurogenesis in adult hippocampus (Ma et al., 2009b), the removal of their methylation through the repair machinery would involve extensive damage to DNA and thus might represent a costly mechanism (Szyf, 2009)
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