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In addition, the chronic expression of the vector protein S gene, in individuals carrying certain HLA haplotypes, could induce immune hyperactivation and excessive production of proinflammatory cytokines, leading to autoimmune hypophysitis or inhibition of ACTH secretion (functional hypopituitarism) (62)

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Although microglia are most known by their activation into anti- or pro-inflammatory states after exposition to injury, these cells retain their homeostatic function, such as inducing neuron survival through IGF-1 secretion