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Research indicates that intravenous, liposomal and sublingual (applied under the tongue) methods of supplementation may be better choices over oral supplementation because they are not broken down during digestion which can prevent adequate absorption
PMID: 37946445
Metabolically, persistent hyperglycemia upregulates glucose transporter-1 (GLUT1), reinforcing a self-perpetuating TGF-1GLUT1 signaling loop in mesangial cells that promotes abnormal extracellular matrix (ECM) accumulation, primarily of collagen and fibronectin (8)
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