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Instead, neuronal GLP-1Rs located outside the BBB primarily serve as peripheral targets for gut-derived or pharmacologically administered GLP-1 (Varin et al., 2019

Pharmacokinetic Parameters Clinical Uses Type 2 diabetes mellitus Obesity management Cardiovascular risk reduction in patients with diabetes Nonalcoholic fatty liver disease (off-label, investigational) Adverse Effects Nausea and vomiting Diarrhea Pancreatitis (rare) Thyroid C-cell tumors (rodent studies) Injection site reactions (if injectable) Comparative Analysis MCQs GLP-1 receptor agonists primarily act on: a) Alpha cells b) Beta cells c) Delta cells d) Hepatocytes Answer: b) Beta cells These drugs increase insulin secretion in a: a) Continuous manner b) Glucose-independent way c) Glucose-dependent way d) Inhibited state Answer: c) Glucose-dependent way Which of the following is a known adverse effect of GLP-1 agonists

Dapagliflozin improves podocytes injury in diabetic nephropathy via regulating cholesterol balance through KLF5 targeting the ABCA1 signalling pathway

So anything that I can do to help the body actually have things that help it work the way that its supposed to go