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Common adverse effects are predominantly gastrointestinal and include: Nausea (reported in 1544% of patients) Vomiting (524%) Diarrhea (830%) Constipation (1124%) Abdominal pain (520%) These effects are typically most pronounced during initial treatment and dose escalation, often diminishing over several weeks as tolerance develops
According to DiMarchi, who worked at Eli Lilly at the time, this was much stronger validation than the acutely decreased appetite witnessed in healthy rats when given the injections of the peptide (RSC
Benvenga S, Bartolone L, Squadrito S, Lo Giudice F, Trimarchi F
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