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B12 is an essential part of our natural biochemistry

Elevated oxidative stress, alongside metabolic dysregulation and inflammation will disrupt energy metabolism, potentially leading to fatigue and other debilitating symptoms characteristic of these conditions

Thus, although E 2 causes genetic changes conducive to its own inactivation, the decrease in estrogenic activity yields a toxicologically active metabolite that constitutes an additional pathway of estradiol-dependent carcinogenesis

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