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A comparative study conducted between GLP-1RA + Metformin in contrast to cyproterone acetate/ethinylestradiol + Metformin in overweight PCOS women, conducted over a period of 12 weeks, implied that GLP-1 RA+Metformin was superior in reducing the waist circumferences as well as preserving blood sugar levels by improved HbA1c levels and regulating menstrual cycle

In clinical literature, the underlying phenomenon relates to how appetite-regulating hormones - particularly GLP-1, ghrelin, and leptin - interact with reward and satiety pathways in the brain

Semaglutide's effects on blood sugar and insulin sensitivity are already working behind the scenes, even if the scale hasn't moved much

The SURMOUNT-4 trial found over 50 percent of tirzepatide weight loss rebounded over 52 weeks