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This feature makes disulfide linkers an attractive option for the design of more effective and safer cancer therapies
The study by Teichman et al
But the study authors named it explicitly as an off-target activity they are working to engineer out, and even speculated that some of the glucose-tolerance benefit might come from it
Protein kinases C (PKC) and golgi-localized -ear-containing ARF binding protein 3 (GGA3) regulate HGF-induced c-Met endocytosis (Kermorgant et al., 2004) to direct fluctuating JNK and paxillin signaling pathways which involve HCC cell migration (Hu et al., 2015)
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