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54,55 Functionally, these classes of drugs strongly and selectively inhibit reabsorption of glucose by renal SGLT-2, thereby resulting in glucosuria, and rearrangement of bodily hemodynamics, such as reduction of arterial blood pressure, depletion of interstitial fluid rather than blood volume that improves both preload and afterload in heart failure, and neuroendocrine factors like the RAAS system

We need to be honest about that distinction

Should I stop GLP-1 if my heart rate increases

Using a technique called target trial emulation, which is designed to mimic the structure of a randomised trial using real-world data, they compared patients starting a GLP-1 medication with patients starting two other classes of diabetes drug: SGLT2 inhibitors and DPP4 inhibitors