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39 TPI deficiency (OMIM 190450) is a relatively rare autosomal recessive multisystem disorder, characterized by hemolytic anemia, severe neuromuscular defects, increased susceptibility to infection, and cardiomyopathy.48,134,161 Patients usually die in childhood, although intriguing exceptions have been reported
The LNPs significantly increase IL-1 production by more than 22-fold and IL-6 synthesis by at least 12-fold, while generating higher antibody levels than AddaVax, an MF59-like adjuvant (98)
It is accessible only through participation in approved clinical trials
Gross CJ & Savaiano DA
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