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This is one of the most interesting potential applications, though formal head-to-head data in this population is limited

Extended interruptions of multiple days warrant protocol reassessment

Given the known risk of quinolone antibiotics interfering with the mitochondrial topoisomerases and ETC-proteins, thereby harming mitochondrial functions 25,26 , CYS were further tested in a Seahorse XF Mito Tox Assay (Agilent) to evaluate mitotoxic risks

Every dose and outcome figure comes from the Novo Nordisk trial programme (REDEFINE 1 and 2, the phase 2 dose-finding trial and the phase 1b combination study) or from their registry records