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Therefore, concurrent agonism at the GLP-1R and GCGR is important for the glucose-lowering effect of OXM: GLP-1R activation offsets the hyperglycaemia associated with GCGR activation

Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer

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Compound 77 demonstrated functional inhibition of PDE10A with a Ki value of 0.029 nM and over 500,000-fold selectivity over other PDE enzymes, making it a promising PDE10A inhibitor (Figures 22A,B)