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Seek urgent care for chest pain, sudden shortness of breath, fainting, or possible stroke symptoms

This is not just a waste of resources

National Natural Science Foundation of China (81500494 and 81873590) to JZ, National Natural Science Foundation of China (81922070), Shanghai City Youth Science and Technology Star Project (19QA1405500) to JZ

Constipation was assessed by frequency of defecation, response to laxatives and feces forms which were classified according to Bristol stool scale, (type 1 = separate hard lumps) (type 2 = sausage shaped and lumpy) (type3 = sausage shaped with cracks on its surface) (type 4 = sausage or snake with smooth surface) (type 5 = soft blobs) (type 6 = fluffy pieces) (type 7 = entirely liquid) 17