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Common Side Effects Reported Across Phase 2 trials, participants experienced dose-dependent GI symptoms that are characteristic of GLP-1 receptor agonists: Nausea most frequent, especially during dose escalation Vomiting typically mild to moderate, subsiding with continued use Diarrhea and constipation fluctuating depending on individual tolerance Abdominal discomfort transient and often improved over time Dose-Response Relationship At lower doses (14 mg weekly), side effects were generally mild and manageable, though some participants still reported early GI symptoms

Potential side effects of semaglutide treatment may include nausea, diarrhea, constipation, or abdominal pain

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For more on prescription access and treatment pathways, our guide to how to get GLP-1 online walks through the process in more detail