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Notably, dexmedetomidine has been shown to exert antioxidative effects by modulating both the NFB and Nrf2 pathways [104]
21 Possible role of the GPX4 gene in the development of CS A possible role of glutathione peroxidase-4 in the development of CS has been summarized in Figure 1
Kraujalis et al., 2013
The approval is based on breakthrough evidence from the landmark EMPA-REG OUTCOME trial, which investigated the effects of JARDIANCE compared with placebo when added to standard of care type 2 diabetes and cardiovascular medicines in adults with type 2 diabetes and established cardiovascular disease
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