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By week 4, most people experience complete resolution of both therapeutic effects and side effects

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doi: 10.1186/s13098-025-02045-4 175 KongXZhaoYWangXYuYMengYYanGet al

Metformin Use with GLP-1 RA: Synergy Towards Better Outcomes Metformin with GLP-RA Effect on Weight-Lowering Response: A 52-week prospective study including 194 obese T2D patients showed concomitant initiation of metformin alongside GLP-1 receptor agonist therapy is associated with enhanced weight loss efficacy, suggesting a potential synergistic metabolic interaction that improves the likelihood of achieving clinically meaningful weight reduction