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This head-to-head randomized trial directly compared tirzepatide with semaglutide for obesity treatment and provides high-level evidence for the magnitude of weight loss achievable with current incretin-based pharmacotherapy
The main effect of endogenous GIP regarding weight is primarily on adipose tissue, where it promotes positive energy balance
D.KruseM.et al (2021)
Multiple dose levels (1, 4, 8, 12 mg) were tested in Phase 2, with the Phase 3 dose selection to be refined based on efficacy-tolerability balance
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