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The glucose lowering activity of GLP-1 is highly transient as the half-life of this hormone in the circulation is less than two minutes
Widespread cases of this side effect have been documented as off-label Ozempic use has increased, leaving users to grapple with the unfortunate trade-off of a slimmer body with sagging, aged-looking facial features
Otherwise, patients may not know what dosage to take and end up over-medicating themselves
This physiological effect, combined with actions on the central nervous system's area postrema (the brain's vomiting centre), can trigger feelings of queasiness, particularly during the initial weeks of treatment
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