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Functions of thiamine Cofactor for enzymes: Pyruvate dehydrogenase -ketoglutarate dehydrogenase Branched-chain ketoacid dehydrogenase Transketolase (HMP shunt) Essential for ATP production Important for neuronal conduction Causes Chronic alcoholism (most common) Malnutrition / starvation Prolonged vomiting, hyperemesis Bariatric surgery Chronic illness, dialysis High-carbohydrate intake without supplementation Infant feeding with thiamine-deficient formula Clinical manifestations 1
2020 Oct 14
Clin Gastroenterol Hepatol 2009;7(11):118994
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