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When ARA-290 binds to the IRR, it initiates several downstream effects: anti-apoptotic signaling (preventing programmed cell death in injured but salvageable cells), suppression of pro-inflammatory cytokine cascades (reducing TNF-, IL-1, and IL-6 production), and inhibition of microglial activation (reducing neuroinflammation in nervous tissue)

Structurally it is a stable gastric pentadecapeptide BPC 157

et al (2019) A geminivirus betasatellite encoded C1 protein interacts withPsbP and subverts PsbP-mediated antiviral defence in plants.Mol

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