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The results mirror a previous observation from our group, that hypothalamic Gipr KO appeared to sensitize DIO mice to weight loss induced by a long-acting GLP-1R agonista finding that had not been the focus of that study and remained unexplained at the time but has since also been observed in global GIPR-KO mice 7,11
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A- If vitamin B12 absorption is impaired or if there is a deficiency state where rapid replenishment is desired, injection therapy is superior
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