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One participant, age 41, reported that adding box breathing (4 seconds in, 4 hold, 4 out) before PFMT sessions noticeably improved his ability to feel the contraction and maintain erection qualitya correlation that makes physiological sense given the role of parasympathetic tone in erections

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385,387 PF1801 displays its anti-inflammatory effects by lowering levels of inflammatory mediators such as TNF, IL-6, and HMGB1, and enhances the cells antioxidant capability by upregulating molecules like Nfe2l2, Hmox1, Gclm, and Nqo1, which further improves cellular defense against oxidative stress and protects them from further damage

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