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Once activated, these caspases cleave gasdermins to liberate the pore-forming N-terminal domains, enabling their targeting of cellular membranes to form large transmembrane pores, which disrupts cellular electrochemical gradient, and leads to water influx and cell swelling (160, 161)

Melittin exhibits toxicity against both A2780CR and A2780 cells, with IC 50 values of 4.5 and 6.8 g/mL, respectively

Similarly, TRIM29, a ubiquitin E3 ligase, functions as an inducible negative regulator of the cGASSTING-mediated innate immune response

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