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Jun 2010;49(4):197-210

Overexpression of nuclear receptor subfamily 1, group D member 1 (NR1D1)/Rev-Erba, an orphan nuclear receptor, has been shown to enhance the antimycobacterial properties of macrophages and decrease the survival of M.tb by promoting phagosomelysosome maturation through IL-10 repression in human macrophages[53]

In major clinical trials, the overall incidence of adverse events for patients taking oral NAC has consistently been comparable to those taking a placebo