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When activated by bitter compounds, they trigger the release of GLP-1, the satiety hormone that tells your brain, Im full , while suppressing the hunger hormone, ghrelin
JAMA 2023;330:163140.ArticlePubMedPMC 37
The meta-analysis of the ELIXA, LEADER, SUSTAIN-6, EXSCEL, Harmony, PIONEER 6, REWIND and AMPLITUDE-O trials shows that the extent of HbA 1c reduction may serve as a proxy for the renal benefits of GLP-1RA therapy
Topical forms remain Category 1 (eligible for compounding)
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