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This step is generally considered the rate-limiting step, with the availability of cysteine and the expression level of GCLC jointly determining the rate of -Glu-Cys production
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Establish baseline thyroid labs, monitor at 6 to 8 weeks, recheck after dose changes and weight milestones, and adjust levothyroxine as needed based on lab results and symptoms
Gupta D, Thappa DM
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