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Kipnis noted that in terms of adverse effects, "anything is possible when an FDA-approved drug is taken inappropriately." What to do in an overdose event Anyone who is taking a prescribed semaglutide should have a primary care physician or medical provider to provide close follow-up support, especially in the first several weeks as the dose increases, Kipnis advised

This confirms that when dry mouth does occur, it is mild and goes away

Journal of Clinical and Translational Science , 7 (1), e184

A meta-analysis of 6 studies 13,20,30,32,33,35 which attempted to estimate overall effect size of the changes from baseline in % FMD following GLP-1-based therapies could not find any significant difference between baseline and end-of-treatment samples (mean change from baseline was 0.83 [1.06, 2.73] %