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British National Formulary
Dedicated randomized controlled trials in women with PCOS, using both metabolic endpoints (fasting insulin, HOMA-IR, glucose tolerance, ideally clamp-based insulin sensitivity) and reproductive endpoints (ovulation, menstrual regularity, free-androgen index, SHBG), with adequate duration and rigorous fertility and pregnancy safeguards
Last but not least, early animal studies suggest that tirzepatide may work well as a multifaceted treatment approach for obesity, type 2 diabetes, and estrogen deficiency
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