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Its central action in research is competitively blocking NNMT's active site, which does two coupled things: it stops the methylation of nicotinamide (a NAD+ precursor) into 1-methylnicotinamide, and it spares S-adenosylmethionine (SAM), the methyl donor the reaction consumes

And so I went for like a year, took myself off the medications for a year last year, and I gained 15 pounds

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