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For a related guide, read what to do after missing a weekly GLP-1 injection

As more people use semaglutide, reports of unexpected side effects are growing: unpleasant changes to your skin and body shape, digestive problems, and unexpected fatigue (sometimes called GLP-1 fatigue.) I want to make you aware of these potential problems so you aren't caught off-guard and left holding your stomach and your head...and wondering why you suddenly look old and feel so tired if you opt for a GLP-1 drug

Garrett Evensen, Edmund Pakhlevanyan, and April Williams of Salk

Safety Considerations and Side Effects A lot of attention needs to be given to IGF-1 LR3 as it is a powerful molecule and has more warnings associated with it than most other peptides: Hypoglycemia risk Because IGF-1 is similar in structure to insulin and can bind to the insulin receptor when present in high concentrations, use of IGF-1 LR3 has been implicated in users experiencing low blood sugar