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"It's good to have more options for patients with obesity," says Melanie Jay, MD, assistant professor of medicine at the NYU Grossman School of Medicine

This binding mode was elucidated through cryo-electron microscopy studies published in the Proceedings of the National Academy of Sciences in 2020, revealing that a small molecule could stabilize the active conformation of a class B G protein-coupled receptor (GPCR) through an entirely novel mechanism

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Laboratory studies suggest that these interactions may influence phosphorylation events and signal transduction processes that regulate endothelial behavior, vascular tone signaling, and angiogenic pathway activity