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Oxygen consumption measurements were performed on intact cells (iPSCs, iNs_D7, and iNs_D14) using the Oxygraph-2 k system, following a protocol including sequential measurement of routine, leak, ETS, and ROX respiration states (Fig

Glutathione plays a vital role in multiple bodily processes, including detoxification, immune system regulation, and the prevention of cellular damage caused by oxidative stress

Receptor Pharmacology and Selectivity Studies Retatrutide is used as a reference compound in tri-receptor binding and activation assays, enabling researchers to compare the relative contributions of GLP-1R, GIPR, and GCGR activation to observed metabolic outcomes and benchmark tri-agonist pharmacology against dual and mono-receptor research compounds