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In the future, there may be an increased focus on multi-agent combination therapy strategies, including the use of radiotherapy sensitizers in combination with chemotherapy, targeted therapy, or immunotherapy
181,183 Inhibition of NOX4 in CAFs reduces ECM stiffness and enhances CD8 T-cell infiltration, restoring immune surveillance and sensitizing tumors to immunotherapy
(2013) Role of glutathione in cancer progression and chemoresistance
These trials collectively reflect the challenges and promise of smart nanocarriers in overcoming drug resistance and improving spatiotemporal control in cancer therapy
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