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A meta-analysis of 80 000 patients found GLP-1 RAs were not associated with an increased risk of optic nerve/vision-threatening events [11], and a recent clinical trial of people taking the highest dose of semaglutide demonstrated excellent safety, increased muscle strength and an increased ratio of lean mass relative to total body mass in people taking semaglutide [12]

Research suggests that when combined, these two peptides may influence GH regulation through complementary mechanisms

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Its important to note that Tirzepatide is not suitable for everyone