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Oxidative stress plays a prominent role in SARS-CoV-2 infection following recognition of the viral S-protein by angiotensin converting enzyme-2 receptor and pattern recognition receptors like toll-like receptors 2 and 4, and activation of transcription factors like nuclear factor kappa B, that subsequently activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) expression succeeded by ROS production

552,554 The protective effect of NAD + on ALS might also be linked to the altered activities of SIRTs, however, the conclusions of many studies are quite different

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Mutagenesis (2015) 30(3):42130